A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among\nthem, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against\nM. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains\n(MIC = 0.625â??6.25 microg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against\ncell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection\nmodel via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class\nof new antitubercular agents with good potential.
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